Download Amyloid Precursor Protein A Practical Approach by Weiming Xia, Huaxi Xu PDF

By Weiming Xia, Huaxi Xu

Within the look for a good therapy for Alzheimer's disorder, APP is a special version protein that illustrates the big choice of uncomplicated and complicated characterization strategies on hand. Exploring quite a few organic thoughts to explain the constitution and serve as of this transmembrane protein, this article offers every one approach with targeted, step by step protocols to accomplish reproducible effects and supply a framework for learning different membrane proteins.

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A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115, 2001. 10. Roncarati, R. et al. The gamma-secretase-generated intracellular domain of betaamyloid precursor protein binds Numb and inhibits Notch signaling. Proc. Natl. Acad. Sci. USA 99, 7102, 2002. 11. Russo, C. et al. Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer’s disease brain.

Mol. Cell. Biol. 19, 5179, 1999. 13. P. et al. The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. J. Biol. Chem. 273, 14761, 1998. 14. L. et al. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J. Biol. Chem. 274, 7952, 1999. 15. , and Marsh, M. Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells. EMBO J. 8, 3641, 1989. 16. S. et al. Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis.

The location of the proteolytic breakdown product, Aβ, is also indicated. fm Page 32 Wednesday, November 3, 2004 2:59 PM (D6b). The transmembrane (TM) region and cytoplasmic tail (D8) are located at the C-terminal end of the molecule. 23 To learn more about this critical domain, we determined its three-dimensional structure by x-ray crystallography. 1). Our intention was to crystallize the intact fragment but trace proteases generated a smaller fragment in the crystallization trials. Nevertheless, the smaller fragment yielded well diffracting crystals that led to the structural determination of GFD.

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