By Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy
Released on account that 1953, Advances in Virus learn covers a various variety of in-depth stories supplying a necessary review of the present box of virology. The influence issue for 2006 is 3.48 putting it seventh within the hugely aggressive classification of virology. * Contributions from prime specialists * Informs and updates on all of the most up-to-date advancements within the box
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Extra resources for Advances in Virus Research, Vol. 72
Similarly DENV-3 genotype III, which belongs to a genetically distinct clade (Fig. , 2003). , 2001). , 2008c). Of particular interest is a particular amino acid difference at position 390 of the E protein, which has been suggested to be a critically determinant of virulence. , 1996). , 2008c). , 2001) and moDCs (Cologna and Rico-Hesse, 2003), as well as to alter virulence for mice (Sanchez and Ruiz, 1996). The putative attenuating property of D390 is further enhanced in chimeras where the Asian genotype 30 -NCR is replaced with the American genotype 30 -NCR (Cologna and Rico-Hesse, 2003), suggesting a synergistic function.
He developed mild arthralgia that lasted nearly a month without any other symptoms. , 2008b). From 1964– 1968, 14 of the 32 strains of DENV isolated from febrile patients were classified as DENV-2, of which 10 strains were isolated in 1966. , 2008b). Although there are no written records on the above patients’ locations of residence or places of exposure, all resided within the Ibadan city limits. Furthermore, the clinical presentation of DENV infection due to these Nigerian sylvatic DENV-2 strains was indistinguishable from classic DF due to endemic DENV (D.
Furcifer). Consequently, sylvatic amplification cycles occur when the population of non-immune non-human primate reservoir hosts rises to sufficient levels to support a transmission cycle. Therefore, should a licensed vaccine lead to the eradication of the endemic transmission cycle in the future, re-emergence of sylvatic strains into the endemic cycle would be limited by homotypic immunity mediated by virus neutralizing antibodies. However, as the experience of previous vector eradication efforts in the Americas can attest, abatement of vector control programs could send any eradication efforts into obsolescence.