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Meant for uncomplicated and medical researchers, immunologists, virologists and molecular biologists, this ebook is a part of a sequence which provides serious overviews on chosen facets of either melanoma examine and the elemental underlying sciences.

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And Levinson, A. D. (1983). Nature (London) 301, Colby, W. , 722-725. Cole, M. D. (1986). Annu. Rev. Genet. 20,361-384. Collins, S.. and Groudine, M. (1982). Nature (London) 298,679-681. Collins, S. , Ruscetti, F. , Gallagher, R. , and Gallo, R. C. (1978). Proc. Natl. Acad. Sci. A. 75,2458-2462. Conklin, K. , and Groudine, M. (1984). In “DNA Methylation” (A. Razin, H. Cedar, and A. D. ), pp. 293-351. Springer-Verlag, New York. , Czernuszewicz. , Postel, E. , Flint, S. , and Hogan, M. E. Science 241,456-459.

Protein inhibition studies in normal and BL cells indicate that protein synthesis, including that of c-myc p64/67, is not required to maintain repression of the nontranslocated c-myc allele, ruling out autorepression by c-myc protein or other labile repressor proteins (Nishikura and Murray, 1988). CONTROL OF c-myc REGULATION 33 3. , 1985a), transcripts that initiate at P I and P2 have the same half-lives in both normal and BL cells (Nishikura and Murray, 1988). At present, the most appealing hypothesis to explain the selective repression of the nontranslocated allele in BL is that these cells would normally shut down c-my transcription, and the nontranslocated allele responds to these signals.

1989). Oncogene 4,549-558. , and. Leder, P. (1983). )34,779-787. , Nordan, R. , Owens, J. , Marcu, K. , and Mushinski, J. F. (1989). Oncogene 4,615-623. Beer, D. , Zweifel, K. , Simpson, D. , and Pitot, H. C. J. Cell. Physiol. 131, 29-35. Bentley, D. , and Groudine, M. Nafure (London) 321,702-706. Bentley, D. , and Groudine, M. Mol. Cell. B i d . 6, 3481-3489. Bentley, D. , Brown, W. , and Groudine, M. (1989). Genes Dev. 3, 1179- I 189. , and Adams, J. M. (1983). EMBOJ. 2, 2375-2383. , Jansen, H.

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