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By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)

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Extra resources for Advances in Cancer Research, Vol. 13

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I n other words, the sporadic effects observed by Haddow (1965) were converted into a response seen in 60% of the treated animals by changing to a more widespread regime for the immunization. The advantage of multiple over single sites of immunization, even when the total number of irradiated tumor cells used is the same, was also apparent from experiments (Parr, 1970) involving the arrest of mouse lymphomas. In one of the tumors, a n effect was only seen following multiple immunization, and a single immunization failed t o arrest the growth of even a very small innoculum of 100 cells.

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